LOUISVILLE, Ky. — Lamar­ Jackson ran for four touchdowns and threw for another as 10th-ranked Louisville poured it on for a 63-20 victory over No. 2 Florida State on Saturday, the most points ever allowed by the Seminoles.

What was billed as an Atlantic Coast Conference showdown was nothing of the sort.

The Cardinals showed off their talent with Jackson leading the way. The quarterback ran for 146 yards and four TDs and passed for 216 yards and a score. The Cardinals’ defense chipped in with five sacks.

Louisville (3-0, 2-0) lost back-to-back halftime leads to Florida State in the past, but the Cardinals left no doubt in topping 60 points for the third straight game. The Seminoles fell to 2-1, 0-1.

Jeremy Smith ran for two TDs for the Cardinals, but Jackson was nearly unstoppable in piling up 362 yards of offense.

He also added to his collection of highlights as he faked one defender and spun off another en route to his final TD run of 47 yards. He has 18 TDs in three games.

‘‘I was proud of how he prepared for the game, how calm he was,’’ Louisville coach Bobby Petrino said after his team positioned itself to crack the Top 5 and make a national championship run. ‘‘He was able to focus and concentrate.’’

Louisville held Florida State to 284 total yards and forced two turnovers.

Dalvin Cook wasn’t a factor in rushing for 54 yards on 16 carries. The Seminoles’ only bright spot was 10 straight points to get within 14-10 before Jackson took over.

‘‘Give credit to Louisville, they did a great job,’’ FSU coach Jimbo Fisher said. ‘‘When you get behind, you play with fire.’’

Jaire Alexander contributed a 69-yard punt return for a touchdown and a fumble recovery leading to another Louisville score. Brandon Radcliff rushed for 118 yards and a score as Louisville won its biggest ACC game before national TV audience.

Many from a Louisville record crowd of 55,632 flooded the field after the final gun to mingle with Cardinals players, with some chanting ‘‘Heisman! Heisman!’’ toward Jackson.