I typically pick four games per week, so here are four teams with plenty of gambling intrigue as we embark on a 21-week quest for profitability.

NEW ENGLAND (2015 record against the spread: 8-8-2): The Patriots are 6-point underdogs in the season opener at Arizona and that number gives everyone a glimpse of what life is like without Tom Brady (for some perspective, the Patriots were 3-point favorites in Denver in the AFC Championship game last January). Keep an eye on the Week 2 and Week 4 spreads, at home against Miami and Buffalo. Those division rivals — and likely underdogs — are going to pull out all the stops to steal a road win against Brady-less New England.

NEW YORK JETS (2015: 8-6-2): I like the Jets, the Raiders, and the Titans as AFC sleepers; their early spreads will bring value. In particular, keep an eye on New York. The Jets have a difficult early schedule and will regularly be catching points — an inviting scenario for a team with solid receivers.

DALLAS (2015: 4-11-1): The Cowboys intrigue me mostly because I bet $100 on them at 15-1 in Las Vegas in June. I was walking into Mandalay Bay’s sports book with a friend and we had every intention of taking Arizona. At the last moment, I asked him what he thought about Dallas, and he asked me why I like giving away my money. Undeterred, I placed my hard-earned cash on the Cowboys, and he followed suit. Beyond my sudden personal tie to Jerry Jones’s club, Dallas bears watching. Even with a rookie mid-round draft pick at quarterback to begin the season, Dallas is a 1-point favorite (at home) against division rival New York. The Cowboys were 1-4 against the spread as favorites last season, and 1-6-1 against the number at home.

CLEVELAND (2015: 6-10): For the first time in years, the Browns seem to have a plan. They have new management, a new — and competent — head coach, and they’ve rid themselves of wasted draft picks. These positives, however, cannot mask the fact they also have a terrible roster. Somehow, Cleveland was favored in four games last season (it went 2-2 against the spread in those contests), and unless Robert Griffin III can jump-start his career, another tough campaign is likely in store. But there is hope, and the Browns could be the kind of team that covers some large spreads as an underdog later in the season because they improved and didn’t quit on the season.

Ed Ryan can be reached at edward.ryaniii@globe.com. Follow him on Twitter @EdzoRyan.